Table 2.
Cox proportional hazards analysis of factors associated with the emergence of hepatotoxicity of any grade
|
Variable |
Univariate analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio ( 95% CI) | P value | |
| Age (per 1-year increase) |
1.021 (0.987-1.057) |
0.230 |
1.025 (0.990-1.061) |
0.162 |
| CD4+ cell count (>250/mm3 vs ≤ 250/mm3) |
1.257 (0.853-1.851) |
0.247 |
1.397 (0.940-2.075) |
0.098 |
| Hemoglobin (<median level of 10.3 g/dl vs ≥ median) |
1.275 (0.897-1.811) |
0.176 |
1.320 (0.924-1.886) |
0.128 |
| Presence of HBV or HCV infection | 1.788 (1.041-3.073) | 0.035 | 1.797 (1.042-3.098) | 0.035 |