Table 3.

Diagnostic characteristics of urine NGAL for CI-AKI, stratified by baseline and postoperative time in all patient (3A), CKD stage III and CKD stage IV (3B)

3A
All patients (N = 130)
	ROC (95% CI)	Cut point (ng/ml)	Sensitivity (%)	Specificity (%)
uNGAL
baseline	0.78 (0.68 to 0.87)	75	77	74
3 h	0.80 (0.69 to 0.89)	104	77	76
6 h	0.85 (0.76 to 0.91)	117	94	78
12 h	0.82 (0.74 to 0.90)	142	88	76
18 h	0.84 (0.76 to 0.91)	161	82	76
24 h	0.86 (0.79 to 0.93)	184	82	81
Delta of uNGAL
0-3 h	0.66 (0.49 to 0.79)	22	85	78
0-6 h	0.83 (0.75 to 0.92)	45	88	80
0-12 h	0.80 (0.72 to 0.89)	71	88	79
0-18 h	0.78 (0.67 to 0.90)	77	82	73
0-24 h	0.79 (0.67 to 0.91)	71	77	74
3B
	CKD stage III (N = 100)				CKD stage IV (N = 30)
	ROC (95% CI)	Cut point (ng/ml)	Sensitivity (%)	Specificity (%)	ROC (95% CI)	Cut point (ng/ml)	Sensitivity (%)	Specificity (%)
uNGAL
baseline	0.72 (0.61 to 0.83)	61	70	71	0.87 (0.73 to 1.0)	84	86	73
3 h	0.79 (0.65 to 0.93)	108	80	78	0.88 (0.75 to 1.0)	155	86	82
6 h	0.82 (0.72 to 0.92)	117	92	80	0.89 (0.80 to 1.0)	207	86	86
12 h	0.77 (0.67 to 0.88)	142	84	75	0.86 (0.72 to 0.99)	281	86	83
18 h	0.81 (0.72 to 0.89)	161	70	76	0.83 (0.68 to 0.97)	285	83	78
24 h	0.82 (0.74 to 0.92)	184	78	81	0.88 (0.75 to 1.0)	235	86	83
Delta of uNGAL
0-3 h	0.80 (0.64 to 0.96)	24	90	78	0.75 (0.49 to 1.0)	22	86	78
0-6 h	0.82 (0.69 to 0.95)	42	91	79	0.89 (0.77 to 1.0)	54	100	87
0-12 h	0.76 (0.64 to 0.88)	65	82	77	0.88 (0.75 to 1.0)	71	100	83
0-18 h	0.80 (0.71 to 0.89)	77	88	73	0.73 (0.47 to 1.0)	102	86	83
0-24 h	0.81 (0.70 to 0.91)	61	80	74	0.73 (0.47 to 0.99)	91	71	78