Table 4.

Diagnostic characteristics of urine NGAL for CI-AKI stage I, stratified by baseline and postoperative time in all patient (4A), CKD stage III and CKD stage IV (4B)

4A
All Patients (N = 130)
	ROC (95% CI)	Cut point (ng/ml)	Sensitivity (%)	Specificity (%)
uNGAL
baseline	0.77 (0.65 to 0.89)	74	77	72
3 h	0.82 (0.71 to 0.94)	108	85	76
6 h	0.83 (0.74 to 0.92)	117	92	76
12 h	0.82(0.72 to 0.91)	142	85	73
18 h	0.84 (0.76 to 0.92)	161	83	74
24 h	0.85 (0.77 to 0.93)	181	85	79
Delta of uNGAL
0-3 h	0.75 (0.58 to 0.91)	22	85	78
0-6 h	0.82 (0.72 to 0.92)	54	85	80
0-12 h	0.79 (0.68 to 0.88)	71	85	76
0-18 h	0.77 (0.63 to 0.91)	77	92	72
0-24 h	0.77 (0.62 to 0.92)	71	77	73
4B
	CKD stage III (N = 100)				CKD stage IV (N = 30)
	ROC (95% CI)	Cut point (ng/ml)	Sensitivity (%)	Specificity (%)	ROC (95% CI)	Cut point (ng/ml)	Sensitivity (%)	Specificity (%)
uNGAL
baseline	0.70 (0.58 - 0.81)	41	78	58	0.90 (0.78 - 1.0)	140	100	88
3 h	0.77 (0.62 - 0.92)	108	78	78	0.89 (0.77 - 1.0)	162	100	79
6 h	0.80 (0.70 - 0.91)	117	89	79	0.89 (0.75 - 1.0)	239	100	80
12 h	0.76 (0.69 - 0.87)	142	78	74	0.83 (0.66 1.0)	276	100	63
18 h	0.80 (0.70 - 0.89)	130	78	72	0.85 (0.68 - 1.0)	242	100	73
24 h	0.82 (0.72 - 0.92)	160	78	79	0.90 (0.78 - 1.0)	184	100	77
Delta of uNGAL
0-3 h	0.79 (0.62 - 0.96)	24	89	77	0.81 (0.64 - 0.97)	22	100	73
0-6 h	0.80 (0.66 - 0.94)	42	89	78	0.84 (0.70 - 0.98)	65	100	77
0-12 h	0.75 (0.63 - 0.89)	74	78	77	0.82 (0.66 - 0.97)	71	100	76
0-18 h	0.81 (0.71 - 0.90)	77	89	73	0.61 (0.19 - 1.0)	102	75	73
0-24 h	0.81 (0.70 - 0.90)	71	78	77	0.62 (0.19 - 1.0)	44	75	54