Table 1. Patient characteristics according to mGFR level in 1609 patients.
| mGFR (ml/min per1.73 m2) | p Value | |||||
| ≥60 | 45–60 | 30–44 | 15–29 | <15 | ||
| (n = 282) | (n = 321) | (n = 472) | (n = 435) | (n = 99) | ||
| Demographic parameters | ||||||
| Men | 188 (66.7) | 233 (72.6) | 321 (68.0) | 274 (63.0) | 56 (56.6) | 0.01 |
| Age (years) | 52.0±15.1 | 58.7±14.4 | 61.0±15.0 | 61.0±15.0 | 60.9±15.2 | <0.0001 |
| African origin | 53 (18.8) | 48 (15.0) | 56 (11.9) | 44 (10.1) | 8 (8.1) | <0.0001 |
| Body mass index (kg/m2) | 25.9±4.9 | 26.3±4.9 | 26.6±4.8 | 26.6±5.0 | 27.0±6.0 | 0.19 |
| Diabetesa | 62 (22.0) | 83 (25.9) | 150 (31.8) | 136 (31.3) | 25 (25.3) | 0.02 |
| Metabolic acidosisb | 6 (2.1) | 11 (3.4) | 47 (10.0) | 100 (23.0) | 46 (46.5) | <0.0001 |
| Hypertensionc | 225 (79.8) | 284 (88.5) | 447 (94.7) | 415 (95.4) | 98 (99.0) | <0.0001 |
| Any antihypertensive treatment | 216 (76.6) | 272 (84.7) | 435 (92.2) | 408 (93.8) | 96 (97.0) | <0.0001 |
| Laboratory parameters | ||||||
| eGFR | 75.9±19.6 | 54.3±12.1 | 39.5±9.8 | 25.4±8.5 | 13.7±5.6 | <0.0001 |
| HDL cholesterol (mmol/L) | 1.36±0.40 | 1.35±0.42 | 1.30±0.44 | 1.24±0.39 | 1.29±0.50 | 0.001 |
| Triglycerides (mmol/L) | 1.1 (0.82–1.6) | 1.2 (0.87–1.6) | 1.4 (0.94–2.0) | 1.4 (1.0–2.1) | 1.5 (1.1–2.3) | <0.0001 |
| Serum albumin (g/L) | 40.2±3.7 | 40.3±3.9 | 39.3±4.5 | 38.8±4.6 | 38.9±5.0 | <0.0001 |
| Prealbumin (g/L) | 0.29±0.07 | 0.30±0.06 | 0.30±0.07 | 0.33±0.0.8 | 0.34±0.08 | <0.0001 |
| Transferrin (g/L) | 2.4±0.42 | 2.3±0.37 | 2.3±0.41 | 2.2±0.40 | 2.13±0.36 | <0.0001 |
| Homocysteine (umol/L) | 13.5±4.3 | 16.9±6.1 | 19.1±6.3 | 21.7±7.6 | 24.0±7.8 | <0.0001 |
| Urinary urea (mmol/24h) | 405.6±118.9 | 381.2±110.7 | 373.3±124.7 | 354.4±113.7 | 297.4±100.8 | <0.0001 |
| WBC count (103/mm3) | 6.1±1.8 | 6.2±2.0 | 6.5±2.3 | 6.8±2.2 | 6.7±1.9 | 0.0001 |
| Plasma fibrinogen (g/L) | 3.4±0.81 | 3.5±0.88 | 3.8±0.93 | 4.2±1.00 | 4.4±0.99 | <0.0001 |
| CRP>10 mg/L | 15 (5.3) | 23 (7.2) | 43 (9.1) | 50 (11.5) | 8 (8.1) | 0.20 |
| Orosomucoid (g/L) | 0.79±0.21 | 0.85±0.22 | 0.92±0.25 | 1.0±0.31 | 1.1±0.23 | <0.0001 |
| Haptoglobin (g/L) | 1.2±0.58 | 1.2±0.58 | 1.4±0.61 | 1.5±0.67 | 1.5±0.69 | <0.0001 |
| Proteinuria (g/24h) | 0.16 (0.10–0.50) | 0.17 (0.11–0.40) | 0.26 (0.13–0.93) | 0.65 (0.23–1.8) | 1.3 (0.55–2.3) | <0.0001 |
Abbreviations: BP, blood pressure; mGFR, measured glomerular filtration rate; HDL, high-density lipoprotein; WBC, white blood cells; CRP, C-reactive protein.
Values are reported as %, mean ± SD or median (interquartile range).
a
Fasting glucose ≥7 mmol/L or HbA1c ≥6.5 or antidiabetic treatment or reported diabetes.
b
Venous CO2 <22 mmol/L or alkaline treatment.
c
Any antihypertensive treatment or systolic BP>140 or diastolic BP>90 mm Hg.