Table 1.
‘Novel’ type 1 diabetes mellitus-associated genes with supplementary evidence
| Gene symbol | Chr. | Start position | Length | SNP† | Gene P-value | Replication P-value | Differential expression P-value | ||
|---|---|---|---|---|---|---|---|---|---|
| RASIP1 | 19 | 49,218,842 | 30,128 | 6 | 4.83E –04 | 2.94E –02 | R2 | 3.18E –03 | ,S1 |
| STRN4 | 19 | 47,217,768 | 36,952 | 5 | 1.97E –04 | 2.67E –02 | R2 | 1.63E –02 | ,S1 |
| BCAR1 | 16 | 75,257,928 | 49,023 | 8 | 9.32E –05 | 2.27E –02 | R2 | 4.17E –02 | ,S1 |
| FYN | 6 | 111,977,485 | 222,142 | 48 | 3.08E –04 | 4.69E –03 | R2 | 2.01E –03 | ,S1 |
| MYL2 | 12 | 111,343,623 | 19,781 | 5 | 4.61E –04 | 8.53E –03 | R3 | 7.58E –03 | ,S1 |
| HLA-J | 6 | 29,968,748 | 13,985 | 1 | 3.49E –06 | 3.89E –02 | R3 | 1.63E –02 | ,S3 |
| PPP1R11 | 6 | 30,029,932 | 13,178 | 4 | 5.50E –06 | 2.99E –02 | R3 | 2.33E –03 1.69E –02 |
,S2 ,S3 |
| ITPR3 | 6 | 33,584,161 | 85,190 | 29 | 4.36E –05 | NS‡ | 4.29E –03 | ,S1 | |
| PLEKHA1 | 10 | 124,129,220 | 67,646 | 11 | 9.92E –05 | NS‡ | 1.04E –02 | ,S1 | |
| ATF7IP | 12 | 14,513,611 | 143,086 | 13 | 8.83E –05 | NS‡ | 2.10E –03 | ,S1 | |
| OR2B6 | 6 | 27,920,019 | 10,941 | 2 | 2.04E –06 | NS‡ | 2.65E –03 | ,S1 | |
| OR5V1 | 6 | 29,318,007 | 11,047 | 2 | 2.16E –06 | NA§ | 3.07E –03 | ,S1 | |
| HIST1H4E | 6 | 26,199,873 | 10,376 | 2 | 3.48E –06 | NA§ | 4.29E –03 | ,S1 | |
| HIST1H2BF | 6 | 26,194,787 | 10,429 | 1 | 6.65E –06 | NS‡ | 8.84E –03 | ,S1 | |
| GUSBL1 | 6 | 26,834,266 | 95,067 | 2 | 3.48E –07 | NA§ | 1.40E –02 | ,S1 | |
| HMGB1 | 13 | 31,027,877 | 17,204 | 2 | 2.07E –04 | NA§ | 1.99E –02 | ,S1 | |
| ZNF192 | 6 | 28,104,716 | 25,520 | 1 | 3.65E –06 | NS‡ | 3.92E –02 | ,S1 | |
| RING1 | 6 | 33,171,286 | 14,213 | 4 | 1.45E –04 | NS‡ | 4.40E –02 | ,S1 | |
| FAM46B | 1 | 27,326,511 | 17,822 | 1 | 6.36E –05 | NA§ | 4.97E –02 2.64E –02 |
,S1 ,S2 |
|
| OLFML3 | 1 | 114,517,030 | 12,845 | 2 | 2.13E –04 | NS‡ | 7.24E –03 1.54E –02 |
,S1 ,S3 |
|
| HIPK1 | 1 | 114,466,996 | 58,426 | 6 | 5.54E –04 | NS‡ | 3.02E –02 3.56E –02 |
,S1 ,S3 |
|
| NSL1 | 1 | 212,894,495 | 75,644 | 12 | 5.48E –05 | NS‡ | 2.27E –02 | ,S2 | |
| IL10 | 1 | 206,935,948 | 14,891 | 8 | 2.28E –04 | NS‡ | 1.05E –02 | ,S2 | |
| TRIM27 | 6 | 28,865,779 | 30,989 | 3 | 8.88E –07 | NS‡ | 8.79E –03 | ,S2 | |
| NCAPD2 | 12 | 6,598,298 | 47,834 | 10 | 1.36E –04 | NS‡ | 1.40E –04 | ,S2 | |
| PPP1R10 | 6 | 30,563,182 | 26,838 | 2 | 4.08E –04 | NS‡ | 3.95E –02 | ,S2 | |
| VPS52 | 6 | 33,213,049 | 31,613 | 2 | 6.73E –07 | NA§ | 1.32E –02 | ,S2 | |
| PHF1 | 6 | 33,373,773 | 15,457 | 2 | 3.14E –04 | NA§ | 6.98E –03 | ,S2 | |
| BAK1 | 6 | 33,535,323 | 17,747 | 7 | 5.18E –05 | NS‡ | 6.11E –03 1.60E –02 |
,S2 ,S3 |
|
| IKZF3 | 17 | 37,916,198 | 109,243 | 7 | 7.54E –05 | NS‡ | 1.87E –04 | ,S3 | |
| ZZEF1 | 17 | 3,902,739 | 148,514 | 23 | 3.55E –04 | NS‡ | 1.46E –03 | ,S3 | |
| GNS | 12 | 65,102,222 | 56,004 | 4 | 6.65E –05 | NS‡ | 1.83E –03 | ,S3 | |
| ORMDL3 | 17 | 38,072,296 | 16,558 | 3 | 7.22E –04 | NS‡ | 2.96E –02 | ,S3 | |
| BRAP | 12 | 112,074,950 | 53,840 | 3 | 1.16E –04 | NS‡ | 4.45E –02 | ,S3 | |
| CRYZL1 | 21 | 34,956,647 | 62,513 | 3 | 3.72E –04 | NA§ | 8.59E –03 | ,S3 | |
| SULT1A1 | 16 | 28,611,913 | 27,953 | 1 | 4.74E –04 | NA§ | 2.61E –02 | ,S3 | |
| TMEM129 | 4 | 1,712,679 | 15,405 | 3 | 7.99E –04 | NS‡ | 4.31E –02 | ,S3 | |
| IKZF1 | 7 | 50,439,231 | 38,568 | 15 | 6.66E –05 | 4.42E –02 | R1 | NA§ | |
| MICA | 6 | −1 | 0 | 3 | 7.52E –05 | 7.52E –05 | R2 | NA§ | |
| PLBD1 | 12 | 14,651,597 | 74,194 | 11 | 3.17E –04 | 3.26E –02 | R2 | NA§ | |
| DEXI | 16 | 11,017,748 | 23,509 | 3 | 8.72E –04 | 3.03E –03 | R2 | NA§ | |
| SBK1 | 16 | 28,298,840 | 41,330 | 7 | 2.28E –05 | 1.37E –02 | R2 | NA§ | |
| GCA | 2 | 163,195,583 | 28,566 | 4 | 9.67E –06 | 4.16E –02 | R3 | NA§ | |
| OR2B3 | 6 | 29,048,985 | 11,105 | 1 | 5.27E –07 | 3.31E –02 | R3 | NA§ | |
| HCP5P2 | 6 | 29,963,782 | 12,246 | 1 | 3.49E –06 | 3.89E –02 | R3 | NA§ | |
| HCG4P3 | 6 | 29,967,622 | 10,983 | 1 | 3.49E –06 | 3.89E –02 | R3 | NA§ | |
| OR2U1P | 6 | 29,225,436 | 11,420 | 5 | 1.05E –06 | 4.73E –02 | R3 | NA§ | |
| VN1R14P | 6 | 26,626,313 | 10,651 | 1 | 6.19E –06 | 2.94E –02 | R3 | NA§ | |
| HCG2P8 | 6 | 29,767,896 | 13,543 | 1 | 6.02E –07 | 3.80E –02 | R3 | NA§ | |
| HCGVIII-2 | 6 | 29,796,425 | 1,1279 | 2 | 4.51E –06 | 4.26E –02 | R3 | NA§ | |
| RPS10P1 | 6 | 26,197,351 | 10,592 | 2 | 3.48E –06 | 4.93E –02 | R3 | NA§ | |
| CCDC101 | 16 | 28,560,249 | 47,862 | 6 | 1.59E –04 | 2.98E –02 | R3 | NA§ | |
| FUT2 | 19 | 49,194,228 | 19,963 | 6 | 3.55E –04 | 3.28E –02 | R3 | NA§ | |
This table includes 53 significant type 1 diabetes mellitus-associated genes with supplemental evidence. Among these 53 genes, 37 were differentially expressed, and 23 genes have been replicated. The first seven genes in this table (RASIP1, STRN4, BCAR1, FYN, HLA-J, PPP1R1 and MYL2) have both differential expression and replication association. The numbers before and after ‘,’ are the differential expression P-value and sample number listed in Table2, respectively.
†
The number of single-nucleotide polymorphisms (SNP) included in a gene.
‡
Not significant in R1, R2 and R3.
§
Not available in R1, R2 and R3.