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. 2014 Apr 3;15:54. doi: 10.1186/1471-2369-15-54

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Copyright © 2014 Edwards et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunolocalization of CLIC4 in WT mice 48 hours after folic acid induced acute kidney injury. Vibratome sections stained with affinity-purified antibody to CLIC4 (red) plus markers for proximal tubule brush border (Lectin LTA, blue) and nuclei (DAPI, cyan). A set of lower magnification image is shown in the upper set (A-C) and a higher magnification set from the same kidney in the lower set (D-F). A and D (left column): CLIC4 signal (red) alone; B and E (center column): merged image of brush border (green) and nuclear (cyan) markers; C and F (right column): merged image of the CLIC4 signal with markers. In the upper set, solid arrow: CLIC4 is tightly polarized to the apical membrane of the dilated proximal tubule which has lost its brush border; solid arrowhead: nuclear localization of CLIC4 is less prominent than in uninjured kidney; open arrow: CLIC4 in a glomerular capillary loop; open arrowhead: CLIC4 in a peritubular capillary. In the lower set, L designates the lumen of the proximal tubule and N labels proximal tubule cell nuclei. A pertiubular capillary is present to the right.