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. 2014 Jul 16;3(5):642–656. doi: 10.1002/mbo3.195

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© 2014 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Domain organization derived from the pam secondary metabolite gene cluster in the genome of Paenibacillus larvae DSM25430. In the genome of P. larvae DSM25430 (NCBI Reference Sequence NC_023134.1) an NRPS/PKS hybrid gene cluster could be identified. The gene cluster of the putative NRP/PK hybrid paenilamicin (pam cluster) consisted of five NRPS, two PKS, and two NRPS/PKS hybrid genes. A, adenylation domain; C, condensation domain; T, thiolation domain; E, epimerization domain; MT, N-methyl transferase; KS, ketosynthetase; AT, acetyltransferase; KR, ketoreductase, and ACP, acyl carrier protein. Domain prediction was performed using SBSPKS (Anand et al. 2010). NRPSs, nonribosomal peptide synthetases; PKSs, polyketide synthases.