Table 1. Characteristics of Acute Non-Lymphocytic Leukemia Cases and Controls in the SETIL Case-Control Study, Italy, 1998-2003.
AnLL cases | Controls matched to AnLL cases | All sampled controls | P valuea | ||||
No. | % | No. | % | No. | % | ||
Genderd | |||||||
Female | 39 | 47.6 | 62 | 48.4 | 482 | 46.2 | |
Male | 43 | 52.4 | 66 | 51.6 | 562 | 52.8 | Na |
Age at study reference date (years)d | |||||||
≤1 | 21 | 25.6 | 35 | 27.3 | 156 | 14.9 | |
2–3 | 13 | 15.9 | 18 | 14.1 | 351 | 33.6 | |
4–5 | 13 | 15.9 | 15 | 11.7 | 233 | 22.3 | |
≥6 | 35 | 42.7 | 60 | 46.9 | 304 | 29.1 | Na |
Residence area (part of Italy)d | |||||||
North (except Lombardy) | 22 | 26.8 | 33 | 25.8 | 250 | 24.0 | |
Lombardy | 16 | 19.5 | 32 | 25.0 | 260 | 24.9 | |
Center | 17 | 20.7 | 23 | 18.0 | 257 | 24.6 | |
South and islands | 27 | 32.9 | 40 | 31.2 | 277 | 26.5 | Na |
Birth order | |||||||
First born | 39 | 47.6 | 68 | 53.1 | 551 | 52.8 | |
Second born | 31 | 37.8 | 39 | 30.5 | 379 | 36.3 | |
Third born and others | 12 | 14.6 | 21 | 16.4 | 113 | 10.8 | 0.49b |
Birth weight (g) | |||||||
<3,000 | 19 | 23.2 | 31 | 24.2 | 239 | 22.9 | |
3,000–3,299 | 18 | 22.0 | 28 | 21.9 | 246 | 23.6 | |
3,300–3,599 | 23 | 28.0 | 29 | 22.7 | 254 | 24.4 | |
≥3,600 | 22 | 26.8 | 40 | 31.2 | 304 | 29.2 | 0.89b |
Duration of breastfeeding (months) | |||||||
0 | 12 | 14.6 | 26 | 20.5 | 232 | 22.3 | |
1–3 | 32 | 39.0 | 32 | 25.2 | 267 | 25.7 | |
4–6 | 19 | 23.2 | 37 | 29.1 | 233 | 22.4 | |
>6 | 19 | 23.2 | 32 | 25.2 | 308 | 29.6 | 0.04b |
Maternal age at child's birth (years) | |||||||
≤24 | 14 | 17.1 | 23 | 18.1 | 140 | 13.4 | |
25–29 | 25 | 30.5 | 41 | 32.3 | 382 | 36.7 | |
30–34 | 30 | 36.6 | 44 | 34.6 | 359 | 34.5 | |
≥35 | 13 | 15.8 | 19 | 15.0 | 160 | 15.4 | 0.65b |
Birth year of the mother | |||||||
<1960 | 15 | 18.3 | 22 | 17.3 | 145 | 13.9 | |
1960–1964 | 27 | 32.9 | 32 | 25.2 | 328 | 31.5 | |
1965–1969 | 22 | 26.8 | 53 | 31.7 | 373 | 35.8 | |
≥1970 | 18 | 22.0 | 20 | 15.8 | 195 | 18.7 | 0.36b |
Maternal educational level | |||||||
Less than high school | 46 | 56.1 | 45 | 35.2 | 400 | 38.4 | |
High school | 26 | 31.7 | 64 | 50.0 | 503 | 48.3 | |
University | 10 | 12.2 | 19 | 14.8 | 139 | 13.3 | <0.01b |
Paternal age at child's birth (years) | |||||||
≤24 | 3 | 3.7 | 6 | 4.7 | 33 | 3.3 | |
25–29 | 18 | 22.2 | 29 | 22.8 | 241 | 23.8 | |
30–34 | 3 | 40.7 | 45 | 35.4 | 385 | 38.0 | |
≥35 | 27 | 33.3 | 47 | 37.0 | 353 | 34.9 | 0.96b |
Paternal educational level | |||||||
Less than high school | 47 | 58.0 | 54 | 42.2 | 463 | 44.6 | |
High school | 24 | 29.6 | 59 | 46.1 | 424 | 40.9 | |
University | 10 | 12.4 | 15 | 11.7 | 151 | 14.6 | 0.06b |
Parental occupational exposure to benzene | |||||||
Absent | 80 | 97.6 | 126 | 98.4 | 1,009 | 96.7 | |
Present | 2 | 2.4 | 2 | 1.6 | 35 | 3.3 | 0.65c |
Abbreviations: AnLL, acute non-lymphocytic leukemia; NA, not appropriate.
Comparison between cases and all controls sampled in the SETIL study (AnLL controls + ALL controls).
P values from χ2 test.
P values from Fisher exact test.
Matching variables.