Table 3. Hematologic and biochemical values (mean ± SEM) in 482 rabbits based on severity of poikilocytosis.
| Analyte | Acanthocytosis | Echinocytosis | Fragmentation | ||||||
| Moderate-marked | None-mild | P value* | Moderate-marked | None-mild | P value* | Mild-moderate | None-rare | P value* | |
| RBC (X106/µl) | 5.8±0.1 | 5.8±0.1 | – | 6.0±0.1 | 5.7±0.1 | 0.0055 | 5.3±0.2 | 5.8±0.1 | 0.0241 |
| HCT (%) | 36.7±0.5 | 37.2±0.3 | – | 38.5±0.5 | 36.6±0.3 | 0.0012 | 34.3±1.1 | 37.2±0.2 | 0.0124 |
| HGB (g/dl) | 12.3±0.1 | 12.5±0.1 | – | 12.9±0.2 | 12.3±0.1 | 0.0055 | 11.1±0.4 | 12.5±0.1 | 0.0006 |
| MCV (fl) | 63.7±0.3 | 64.6±0.2 | 0.0454 | 64.6±0.3 | 64.2±0.2 | – | 65.3±0.8 | 64.3±0.2 | – |
| MCH (pg) | 21.4±0.1 | 21.7±0.1 | – | 21.5±0.1 | 21.6±0.1 | – | 20.9±0.3 | 21.6±0.1 | 0.0243 |
| MCHC (g/dl) | 33.6±0.1 | 33.6±0.1 | – | 33.4±0.1 | 33.7±0.1 | – | 32.1±0.3 | 33.7±0.1 | <0.0001 |
| RDW (%) | 13.8±0.1 | 13.2±0.1 | 0.0008 | 13.4±0.1 | 13.4±0.1 | – | 16.1±0.3 | 13.3±0.1 | <0.0001 |
| POLY (%) | 1.3±0.1 | 1.2±0.04 | – | 1.3±0.1 | 1.2±0.04 | – | 1.8±0.1 | 1.2±0.03 | 0.0002 |
| WBC (/µl) | 7677±264 | 7509±178 | – | 8036±287 | 7393±171 | – | 8493±646 | 7510±151 | – |
| HET (/µl) | 3780±211 | 3663±142 | – | 4022±230 | 3585±137 | – | 4914±515 | 3632±120 | 0.0159 |
| LYM (/µl) | 2940±143 | 2970±96 | – | 3008±156 | 2944±93 | – | 2562±351 | 2983±82 | – |
| MONO (/µl) | 525±38 | 510±26 | – | 606±41 | 483±24 | 0.0116 | 679±94 | 506±22 | – |
| EOS (/µl) | 89±8 | 84±5 | – | 80±8 | 88±5 | – | 81±19 | 86±4 | – |
| BASO (/µl) | 314±19 | 261±13 | 0.0226 | 278±21 | 277±12 | – | 238±47 | 280±11 | – |
| PLT (X103/µl) | 630±25 | 579±16 | – | 609±27 | 588±15 | – | 764±62 | 586±13 | 0.0057 |
| MPV (fl) | 7.4±0.2 | 7.2±0.1 | – | 7.7±0.2 | 7.1±0.1 | 0.0105 | 8.4±0.5 | 7.2±0.1 | 0.0228 |
| TPP (g/dl) | 7.2±0.1 | 7.1±0.04 | – | 7.3±0.1 | 7.1±0.1 | – | 7.1±0.1 | 7.2±0.04 | – |
| FIB (mg/dl) | 303±16 | 312±10 | – | 340±17 | 298±10 | 0.0377 | 408±38 | 304±9 | 0.0076 |
| AG (mmol/L) | 25.4±0.6 | 24.8±0.4 | – | 27.1±0.6 | 24.1±0.4 | 0.0001 | 26.3±1.7 | 25.0±0.3 | – |
| Na (mmol/L) | 144.0±0.4 | 143.6±0.2 | – | 144.6±0.4 | 143.4±0.2 | 0.0079 | 143.2±1.0 | 143.8±0.2 | – |
| K (mmol/L) | 4.6±0.1 | 4.4±0.1 | 0.0202 | 4.6±0.1 | 4.4±0.1 | 0.0271 | 5.0±0.2 | 4.4±0.04 | 0.0077 |
| Cl (mmol/L) | 102.9±0.4 | 102.5±0.3 | – | 103.6±0.5 | 102.3±0.3 | 0.0246 | 102.8±1.2 | 102.6±0.2 | – |
| HCO3 (mmol/L) | 20.3±0.5 | 20.9±0.3 | – | 18.5±0.4 | 21.6±0.3 | <0.0001 | 19.1±1.2 | 20.8±0.2 | – |
| CA (mg/dl) | 14.7±0. 1 | 14.4±0.1 | – | 14.5±0.1 | 14.5±0.1 | – | 14.2±0.3 | 14.5±0.1 | – |
| PHOS (mg/dl) | 3.6±0.2 | 3.7±0.1 | – | 4.0±0.2* | 3.5±0.1 | 0.0331 | 3.5±0.5 | 3.7±0.1 | – |
| BUN (mg/dl) | 24.3±2.0 | 23.2±1.3 | – | 26.7±2.1 | 22.4±1.3 | – | 29.1±5.0 | 23.3±1.1 | – |
| CREA (mg/dl) | 1.3±0.1 | 1.4±0.1 | – | 1.7±0.1 | 1.3±0.1 | 0.0148 | 1.6±0.3 | 1.4±0.1 | – |
| GLU (mg/dl) | 164.7±4.0 | 166.4±2.7 | – | 158.3±4.3 | 168.6±2.6 | 0.0424 | 146.2±10.2 | 166.8±2.3 | 0.0482 |
| T. PROT (g/dl) | 7.3±0.2 | 6.9±0.1 | – | 7.0±0.2 | 7.1±0.1 | – | 6.9±0.5 | 7.1±0.1 | – |
| ALB (g/dl) | 5.3±0.1 | 5.2±0.1 | – | 5.1±0.1 | 5.2±0.1 | – | 4.4±0.2 | 5.3±0.04 | <0.0001 |
| GLOB (g/dl) | 1.7±0.1 | 1.97±0.1 | – | 1.9±0.1 | 1.7±0.1 | – | 2.5±0.2 | 1.7±0.05 | 0.0010 |
| CHOL (mg/dl) | 58.1±3.9 | 43.5±2.6 | 0.0044 | 57.3±4.2 | 44.3±2.6 | 0.0094 | 93.5±9.9 | 45.6±2.2 | <0.0001 |
| T. BILI (mg/dl) | 0.1±0.1 | 0.2±0.1 | – | 0.1±0.1 | 0.2±0.1 | – | 0.1±0.2 | 0.2±0.1 | – |
| ALT (U/L) | 50±17 | 81±11 | – | 57±18 | 77±11 | – | 66±44 | 71±10 | – |
| AST (U/L) | 44±62 | 129±42 | – | 64±67 | 116±41 | – | 63±159 | 104±36 | – |
| ALP (U/L) | 62±8 | 77±6 | – | 60±9 | 77±6 | – | 87±22 | 71±5 | – |
| CK (U/L) | 1244±430 | 2198±298 | – | 2429±465 | 1680±289 | – | 6567±1110 | 1658±246 | <0.0001 |
| GGT (U/L) | 10±2 | 12±1 | – | 11±2 | 11±1 | – | 19±5 | 11±1 | – |
| N | 118–150 | 245–332 | – | 101–127 | 262–355 | – | 16–25 | 346–457 | – |
*Student’s t test between rabbits having moderate-marked (>3% of RBCs) vs none-mild (≤3% of RBCs) acanthocytes or echinocytes, or mild-moderate (>0.5% of RBCs) vs none-rare (≤0.5% of RBCs) fragmented red cells.
– indicates no significant difference.