Table 1.
True marginal probability of toxicity, marginal probability of efficacy and D ( z ) for each dose level
| Scenario | Dose | ||||
|---|---|---|---|---|---|
| |
|
1 |
2 |
3 |
4 |
| 1 |
P(Toxicity) |
0.05 |
0.12 |
0.27 |
0.50 |
| |
P(Efficacy) |
0.38 |
0.55 |
0.71 |
0.83 |
| |
D(z) |
-0.38 |
-0.03 |
0.16 |
-0.07 |
| 2 |
P(Toxicity) |
0.38 |
0.52 |
0.67 |
0.79 |
| |
P(Efficacy) |
0.77 |
0.82 |
0.86 |
0.89 |
| |
D(z) |
0.08 |
-0.11 |
-0.38 |
-0.6 |
| 3 |
P(Toxicity) |
0.02 |
0.07 |
0.15 |
0.31 |
| |
P(Efficacy) |
0.12 |
0.25 |
0.45 |
0.67 |
| |
D(z) |
-0.96 |
-0.67 |
-0.26 |
0.04 |
| 4 |
P(Toxicity) |
0.05 |
0.11 |
0.25 |
0.46 |
| |
P(Efficacy) |
0.18 |
0.55 |
0.79 |
0.86 |
| |
D(z) |
-0.82 |
-0.02 |
0.32 |
0.03 |
| 5 |
P(Toxicity) |
0.03 |
0.08 |
0.18 |
0.38 |
| |
P(Efficacy) |
0.18 |
0.25 |
0.33 |
0.43 |
| D(z) | -0.82 | -0.67 | -0.53 | -0.48 |
Optimal dose is in bold.