Scheme 2. Synthesis of 6-Chloro-7-methoxy-2-methyl-3-aryl-4(1H)-quinolones.
Reagents and conditions: (a) I2, Na2CO3, MeOH, rt. (b) ArB(OH)2, SPHOS, K3PO4, toluene or DMF, 80–100 °C, 0.5–48 h. (c) EtI, Cs2CO3, DMF, 5 h, rt. (d) HBr, reflux, 15 min.
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