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Reagents and conditions: (a) aniline, Ti(OiPr)4, diethylaluminum cyanide, DCE, rt, 24 h, 74%; (b) NH3/MeOH, Raney Ni, 2.7 atm H2(g), 24 h, 78%; (c) 1,3-di-Boc-2-(carboxymethyl)guanidine, HOBt, EDCI, Et3N, DCM, 0 °C → rt, 20 h, 37%; (d) TFA, DCM, rt, 6 h, 65%.
