Table 1.
HIF-1 regulated transcripts
| Gene description | Gene symbol | Fold change HX/NX |
|---|---|---|
| Leptin |
LEP |
74.3 |
| Insulin-like growth factor binding protein 1 |
IGFBP1 |
8.93 |
| Phopshoglycerate kinase |
PGK |
7.10* |
| Lysyl oxidase-like 4 |
LOXL4 |
6.5 |
| Carbonic anhydrase IX |
CA9 |
5.55 |
| Metallothionein 3 |
MT3 |
4.78 |
| Vascular Endothelial Growth Factor A |
VEGFA |
4.61 |
| Carbonic anhydrase XII |
CA12 |
4.62 |
| Lysyl Oxidase |
LOX |
3.99 |
| Basic helix-loop-helix family member 40 |
BHLHE40 |
3.97 |
| Adrenomedullin |
ADM |
3.39 |
| Placental Growth Factor |
PGF |
3.28 |
| Phosphofructokinase |
PFK |
3.20* |
| Insulin-like growth factor binding protein 3 |
IGFBP3 |
3.10 |
| Angiopoietin-like 4 |
ANGPTL4 |
2.88 |
| BCL2/adenovirus E1B 19 kDa interacting protein 3 |
Bnip3 |
2.17 |
| Lactate Dehydrogenase-A |
LDH-A |
2.10 |
| Glyceraldehyde-3-Phosphate Dehydrogenase |
GAPDH |
1.48* |
| PhopshoGlycerate Mutase |
PGAM |
0.70* |
| Solute carrier family 2 (facilitated glucose transporter), member 1 |
SLC2A1 (GLUT 1) |
2.01 |
| Solute carrier family 2 (facilitated glucose transporter), member 3 | SLC2A1 (GLUT 3) | 2.11 |
Genes were identified from the gene expression array and all values are significant (p < 0.05, n = 3). For genes with (*), transcripts were quantified by QPCR using 3 different preparations of hMSCs run in duplicate; (PGK p < 0.001; PFK, p < 0.01; GAPDH, p = 0.21; PGAM, p = 0.02; all n = 7).