Table 3.
Down-regulated genes and functional group allocations
| Class | Gene description | Gene symbol | HX/NX |
|---|---|---|---|
|
Antioxidant | |||
| |
NAD(P)H dehydrogenase, Quinone 1 |
NQO1 |
−5.63 |
| Aldo-Keto Reductase 1C1 |
AKR1C1 |
−2.71 |
|
| Aldo-Keto Reductase 1C2 |
AKR1C2 |
−2.61 |
|
| Aldo-Keto Reductase 1C3 |
AKR1C3 |
−2.60 |
|
| Aldo-Keto Reductase 1C4 |
AKR1C4 |
−4.28 |
|
| Aldo-Keto Reductase1D1 |
AKR1D1 |
−3.04 |
|
| Aldo-Keto Reductase 1B10 |
AKR1B10 |
−3.07 |
|
| Aldo-Keto Reductase 1B15 |
AKR1B15 |
−2.10 |
|
| Glucose 6 phosphate DH |
G6PDH |
−2.00 |
|
| Thioredoxin reductase |
TXNRD1 |
−3.77 |
|
|
Proliferation/growth associated | |||
| |
Insulin-like growth factor 1 |
IGF-1 |
−3.2 |
| PI3-kinase regulatory subunit 2 |
PIK3R2 |
−2.9 |
|
| Platelet derived growth factor receptor-like |
PDGFRL |
−2.85 |
|
| Fibroblast growth factor 7 |
FGF7 |
−2.1 |
|
| Cell cycle arrest checkpoint |
RAD9B |
−4.4 |
|
| Mediator of DNA damage checkpoint 1 |
MDC1 |
−3.39 |
|
| Helicase (DNA) B |
HELB |
−4.4 |
|
| Inhibitor of DNA binding 1 |
ID1 |
−3.26 |
|
| Inhibitor of DNA binding 2 |
ID2 |
−3.0 |
|
| Inhibitor of DNA binding 4 |
ID4 |
−3.0 |
|
| TNF superfamily, member 14 |
TNFSF14 |
−2.22 |
|
|
Migration-associated | |||
| |
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
PREX1 |
−2.23 |
| Coronin 7 |
CORO7 |
−5.10 |
|
| Formin homology 2 domain containing 1 |
FHOD1 |
−2.15 |
|
| Actin filament associated protein 1 like 2 |
AFPAP1L2 |
−3.3 |
|
| Palmdelphin |
PALMD |
−2.8 |
|
| Tubulin, alpha 3D |
TUBA3D |
−3.9 |
|
|
Glucose metabolism | |||
| |
Glucose 6 phosphate DH |
G6PDH |
−2.00 |
| Pyruvate dehydrogenase (liver RBC) |
PKLR |
−2.61 |
|
| Phosphoglycerate mutase 2 |
PGAM2 |
−3.00 |
|
| Phosphoglycerate mutase 5 |
PGAM5 |
−2.27 |
|
| Phosphogluconate dehydrogenase |
PGD |
−2.55 |
|
| Glucose transporter, member 4 |
SLC2A4 |
−2.7 |
|
| Glucose transporter, member 8 |
SLC2A8 |
−2.5 |
|
| Glucose/fructose transporter, member 11 |
SLC2A11 |
−2.24 |
|
|
Muscle/myogenesis/structural | |||
| |
Actin alpha-1 (Sk) |
ACTA1 |
−4.33 |
| Actin gamma-2 (SM) |
ACTG2 |
−5.83 |
|
| Fer-1-like 5 (myotube formation) |
FER1L5 |
−5.30 |
|
| Tripartite motif containing 16-like |
TRIM16L |
−4.95 |
|
| Myosin heavy chain 2 |
MYH2 |
−4.0 |
|
| Myosin heavy chain 7 |
MYH7 |
−3.0 |
|
| Troponin T type 2 (cardiac) |
TNNT2 |
−2.8 |
|
| ATPase calcium channel (cardiac) |
ATP2A1 |
−2.94 |
|
| Myosin binding protein B (fast) |
MYBPC2 |
−2.79 |
|
|
Miscellaneous | |||
| Lysine acetyl transferase 2A |
KAT2A |
−3.45 |
|
| Galactosidase beta-1-like (senescence) |
GLB1L3 |
−3.0 |
|
| Eukaryotic translation initiating factor 2B subunit gamma 3 |
EIF2B3 |
−2.6 |
|
| Eukaryotic translation elongating factor 1 epsilon 1 |
EEF1E1 |
−2.67 |
|
| Osteocrin |
OSTN |
−2.3 |
|
| Elongation factor RNA Pol II, 2 |
ELL2 |
−2.0 |
|
| Telomerase associated protein-1 |
TEP1 |
−2.67 |
|
| Death associated protein kinase 2 |
DK2 |
−2.4 |
|
| Protein kinase C delta |
PRKCD |
−3.37 |
|
| Interleukin-8 |
IL8 |
−3.05 |
|
| Interleukin-19 |
IL19 |
−2.61 |
|
| Interleukin-27 |
IL27 |
−3.30 |
|
| Interleukin-28A |
IL28A |
−2.24 |
|
| Chemokine (C-C motif) ligand 2 | CCL2 | −3.19 | |
Genes were identified from the gene expression array using Genespring software and GO analysis to assign functional categories as described in Methods; additional genes were identified manually from inspection of the arrays. All values are significant (p < 0.05, n = 3).