Table 1.
List of the inferred clusters in the presence of recurrent trans-factors
| Class | Cluster | Trans-factors |
|---|---|---|
| RBP |
Clust R01 |
AGO1, AGO2, ELAVL1, FMR1_iso1, FMR1_iso7, |
| |
|
FXR2, LIN28A, LIN28B, MOV10, TIA1, TIAL1, |
| |
|
ZC3H7B |
| RBP |
Clust R02 |
AGO1, AGO2, ELAVL1, IGF2BP1, IGF2BP2, |
| |
|
IGF2BP3, TIAL1 |
| Singleton |
Clust R03 |
AGO1 |
| RBP |
Clust R04 |
ELAVL1, HNRNPD |
| RBP |
Clust R05 |
AGO1, AGO2, ELAVL1, EWSR1, FMR1_iso1, |
| |
|
FUS, LIN28A, LIN28B, TAF15, TIA1, TIAL1, |
| |
|
ZC3H7B |
| RBP |
Clust R06 |
AGO1, ELAVL1, TIA1, TIAL1 |
| RBP |
Clust R07 |
AGO1, FMR1_iso1, FMR1_iso7 |
| RBP |
Clust R08 |
AGO1, AGO2, CAPRIN1, ELAVL1, FMR1_iso1, |
| |
|
FMR1_iso7, LIN28B, TIA1, TIAL1, ZC3H7B |
| RBP |
Clust R09 |
AGO1, AGO2, C22ORF28, ELAVL1, FMR1_iso1, |
| |
|
FMR1_iso7, LIN28B, TIA1, TIAL1, ZC3H7B |
| RBP-miRNA |
Clust R10 |
LIN28A, LIN28B, hsa-miR-221* |
| RBP |
Clust R11 |
AGO1, HNRNPH |
| RBP |
Clust R12 |
AGO1, AGO2, ELAVL1, FMR1_iso1, HNRNPC, |
| |
|
TIA1, TIAL1 |
| Singleton |
Clust R13 |
PUM1 |
| RBP |
Clust R14 |
AGO1, AGO2, ELAVL1, FMR1_iso1, FMR1_iso7, |
| |
|
HNRNPU, TIA1, TIAL1 |
| RBP |
Clust R15 |
AGO1, AGO2, ELAVL1, FMR1_iso1, FMR1_iso7, |
| |
|
HNRNPF, TIA1, TIAL1 |
| RBP |
Clust R16 |
AGO1, AGO2, ELAVL1, EWSR1, FMR1_iso1, |
| |
|
FMR1_iso7, FXR1, FXR2, LIN28A, LIN28B, TIA1, |
| |
|
TIAL1, ZC3H7B |
| RBP |
Clust R17 |
AGO1, AGO2, ELAVL1, FMR1_iso1, IGF2BP1, |
| |
|
IGF2BP2, IGF2BP3, PUM2, TIA1, TIAL1 |
| Singleton |
Clust R18 |
PABPC1 |
| Singleton |
Clust R19 |
U2AF2 |
| RBP-miRNA |
Clust R20 |
AGO1, AGO2, ELAVL1, FMR1_iso1, IGF2BP1, |
| |
|
IGF2BP2, IGF2BP3, TIA1, TIAL1, hsa-miR-130a, |
| |
|
hsa-miR-130b, hsa-miR-148a, hsa-miR-148b, |
| |
|
hsa-miR-301a, hsa-miR-301b |
| RBP-miRNA |
Clust R21 |
AGO1, AGO2, ELAVL1, FMR1_iso1, IGF2BP1, |
| |
|
IGF2BP2, IGF2BP3, TIA1, TIAL1, hsa-miR-15a, |
| |
|
hsa-miR-15b, hsa-miR-16, hsa-miR-424 |
| Singleton |
Clust R22 |
DGCR8 |
| RBP-miRNA |
Clust R23 |
AGO1, AGO2, ELAVL1, FMR1_iso1, IGF2BP1, |
| |
|
IGF2BP2, IGF2BP3, TIA1, TIAL1, hsa-miR-106b, |
| |
|
hsa-miR-17, hsa-miR-20a, hsa-miR-320, |
| |
|
hsa-miR-93 |
| RBP-miRNA |
Clust R24 |
AGO1, AGO2, ELAVL1, IGF2BP1, IGF2BP2, |
| |
|
IGF2BP3, TIAL1, hsa-let-7a, hsa-let-7b, |
| |
|
hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, |
| |
|
hsa-let-7g, hsa-let-7i |
| RBP |
Clust R25 |
AGO1, AGO2, ELAVL1, FMR1_iso1, |
| HNRNPA2B1, TIA1, TIAL1 |
Clusters were classified according to their composition: “RBP” for those composed exclusively of RBPs; “miRNA”, composed exclusively of miRNAs; “RBP-miRNA”, composed of both RBPs and miRNAs; and “Singleton”, composed of only one trans-factor.