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. 2014 Nov 17;9(11):e113039. doi: 10.1371/journal.pone.0113039

Table 4. Results of Cox regression analysis of significant independent clinicopathological actors and high tumour stromal expression of mir-21 versus BF and CF.

Biochemical Failure (BF) Clinical Failure (CF)
Variable HR (95% CI) p HR (95% CI) p
pT-Stage pT2 1 <0.001 Not Significant
pT3a 1.7 (1.1–2.5) 0.011
pT3b 2.6 (1.6–4.2) <0.001
Preop PSA 1.4 (1.0–1.9) 0.069 Not Significant
Gleason 3+3 1 0.021 1 0.013
3+4 1.0 (0.7–1.5) 0.999 2.7 (0.9–8.6) 0.085
4+3 1.5 (0.9–2.4) 0.125 3.5 (1.0–12.1) 0.047
8–10 1.9 (1.3–2.7) 0.008 6.6 (2.1–21.2) 0.002
Perineural infiltration Not Significant 2.3 (1.1–4.7) 0.031
Vascular infiltration Not Significant Not Significant
Apical PSM 0.6 (0.4–0.8) 0.003 Not Significant
Non-apical PSM 1.9 (1.3–2.7) <0.001 2.9 (1.4–6.1) 0.004
hsa -miR-21 1.4 (1.0–1.9) 0.089 Not Significant