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(A and B) FIIN-2 (purple stick) covalently binds to Cys477 in the P-loop of FGFR4 (green ribbons) and results in the DFG-out conformation of FGFR4. (C) FIIN-3 (pink stick) binds to Cys477 of FGFR4 V550L (green ribbons) with a similar binding mode. (D) FIIN-3 binds to Cys797 of EGFR L858R (blue ribbons) covalently and in a DFG-in conformation.
