Fig. 4.

Circadian disease genes and drug targets. (A) Overlap between circadian genes, known disease-associated genes, and drug targets. Sources for disease genes and drug targets are included in SI Methods. (B) Example of a common drug having an oscillatory gene target: expression profiles for the aspirin target Ptgs1 from heart, lung, and kidney. Traces from these organs for the mir22 host gene, predicted to target Ptgs1, are also shown. (C) Number of PubMed references for circadian vs. noncircadian genes.