Table 1.
Drugs of the top-100 best-seller list that target circadian genes and have half-life < 6h
| Rank | Sales, $ | Trade name | Indications | Circadian-gene targets | Organs in which targets oscillate |
| 2 | 1.46 b | Nexium | Gastritis, GERD, Esophagitis | Atp4a | L |
| 5 | 1.28 b | Advair Diskus | Asthma, Chronic obstructive pulmonary di... | Serpina6, Pgr, Nr3c2, Adrb2, Pla2g4a | Lu, H, L, K, S, A |
| 11 | 794 m | Rituxan | Rheumatoid arthritis, Non-Hodgkin's lymp... | Fcgr2b, Ms4a1, Fcgr3 | L, K, S |
| 20 | 538 m | Diovan | Hypertension, Heart failure | Slc22a6, Agtr1a, Slco1b2, Car4, Kcnma... | H, AG, L, K, S |
| 27 | 431 m | Vyvanse | Attention deficit hyperactivity disorder | Adra1b | L |
| 32 | 392 m | Tamiflu | Influenza | Neu2, Neu1, Ces1g, Slc22a8, Slc15a1, ... | Lu, L, BF, K, C |
| 33 | 383 m | Ritalin | Attention deficit hyperactivity disorder | Slc6a4 | AG, K |
| 37 | 348 m | AndroGel | Hypogonadism | Slc22a4, Slc22a3, Ar, Cyp1a1, Cyp2b10... | Lu, H, BS, WF, AG... |
| 38 | 346 m | Lidoderm | Pain | Slc22a5, Cyp2b10, Egfr, Abcb1a | Lu, H, AG, BF, L,... |
| 44 | 304 m | Seroquel XR | Bipolar disorder, Major depressive disor... | Htr2c, Htr1b, Htr2a, Chrm2, Drd4, Adr... | Lu, H, BS, WF, AG... |
| 45 | 289 m | Viagra | Erectile dysfunction | Cyp1a1, Pde6g, Abcc5, Abcc10, Pde5a, ... | Lu, H, BS, WF, AG... |
| 47 | 281 m | Niaspan | Hyperlipidemia | Slco2b1, Slc22a5, Qprt, Slc16a1 | Lu, H, BS, AG, WF... |
| 48 | 279 m | Humalog | Diabetes mellitus T2 | Igf1r | K |
| 49 | 274 m | Alimta | Mesothelioma, Nonsmall cell lung cancer | Tyms, Atic, Gart, Slc29a1 | Lu, H, BS, BF, L,... |
| 54 | 267 m | Combivent | Asthma, Chronic obstructive pulmonary di... | Slc22a5, Slc22a4, Chrm2, Adrb1, Adrb2 | Lu, H, BS, BF, K,... |
| 56 | 262 m | ProAir HFA | Asthma, Chronic obstructive pulmonary di... | Adrb1, Adrb2 | Lu, K, S |
| 62 | 240 m | Janumet | Diabetes mellitus T2 | Slc47a1, Slc22a2, Prkab1, Abcb1a, Dpp4 | H, BS, AG, Hy, L,... |
| 66 | 236 m | Toprol XL | Hypertension, Heart failure | Slc22a2, Adrb1, Adrb2, Abcb1a | Lu, H, AG, BF, L,... |
| 71 | 220 m | Vytorin | Hyperlipidemia | Hmgcr, Cyp2b10, Soat1, Abcc2, Anpep, ... | Lu, H, BS, AG, BF... |
| 78 | 209 m | Aciphex | Gastritis, GERD, Esophagitis | Cyp1a1, Atp4a, Abcg2 | Lu, H, BS, WF, L,... |
| 90 | 189 m | Lunesta | Insomnia | Ptgs1, Tspo, Gabra3 | Lu, H, AG, K |
| 98 | 173 m | Prilosec | Gastritis, GERD, Esophagitis | Cyp1a1, Atp4a, Abcg2, Cyp1b1, Abcb1a | Lu, H, BS, WF, AG... |
| 99 | 171 m | Focalin XR | Attention deficit hyperactivity disorder | Slc6a4 | AG, K |
Rank and sales are based on USA 2013 Q1 data from Drugs.com. A, aorta; AG, adrenal gland; BF, brown fat; BS, brainstem; C, cerebellum; H, heart; Hy, hypothalamus; K, kidney; L, liver; Lu, lung; S, skeletal muscle; WF, white fat.