Fig. 3.

Dlk1-overexpressing mice are capable of adipose expansion and are resistant to hepatosteatosis, on an obesogenic genetic background. Body weights of WT ob/ob and WT/TG ob/ob mice from 3–24 wk of age, males (A), n ≥ 6 and females (B), n ≥ 5. (C) Body composition of male mice at 24 wk, n as in A. (D) Liver weight in WT/TG ob/ob mice compared with WT ob/ob mice as a total weight or % body weight, n ≥ 6 males. (E) H&E staining of representative liver sections from fasted male (four, Left) and female (four, Right) mice at 24 wk at 200× magnification. TAG deposition appears as circular “empty” droplets. Values are mean ± SEM, *P < 0.05 by Mann–Whitney U test.