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WT mice accumulate more BER intermediates and fewer 8-oxoG DNA lesions than Aag−/− mice. (A) The level of abasic sites (AP sites) 24 h after I/R treatment in liver DNA isolated from WT and Aag−/− mice. (B) εA, εG, and 8-oxoG base lesions in liver DNA isolated from WT and Aag−/− mice after ischemia followed by 6 h of reperfusion. Error bars represent the mean ± SEM of at least three independent experiments.
