Skip to main content
. 2014 Nov 17;9(11):e113020. doi: 10.1371/journal.pone.0113020

Figure 6. Percent of insulin content secreted from intact islets after static incubation at 2.8, 10, and 16.7 mM glucose with and without treatment.

Figure 6

Untreated control samples are shown in white. A, Percent of insulin content secreted at 2.8, 10, and 16.7 mM glucose concentrations in the presence and absence of GLP-1 (20 nM, light gray), the Gβγ inhibitor, gallein (10 µM, checked), or combination treatment with gallein and GLP-1 (striped). B, Percent of insulin content secreted at 2.8, 10, and 16.7 mM glucose concentrations with GLP-1 (20 nM, light gray), the Gβγ-activating peptide mSIRK (30 µM, checked), or combination treatment with mSIRK and GLP-1 (striped). Data are the mean ± S.E. n = 4–19. *(p<0.05) and **(p<0.001) indicate significance compared to untreated control, GLP-1 only, or gallein alone.