Table 2. Summary of Histological Lesions in Balb/C Mice on PLX regimen.

	No Treatment		Vehicle (Gavage Control)			Long Pepper Extract (Treatment group)
	M1	M2	M1	M2	M3	M1	M2	M3	M4
Liver:
-Infiltration, leukocyte, predominantly mononuclear, minimal		X	X		X	X			X
-Focal mineralization, minimal
-Hepatocyte necrosis, minimal									X
-Focus of cellular alteration, eosinophilic, minimal			X	X				X
-Hepatocyte vacuolation, lipid type, minimal			X	X			X
- Hepatocyte vacuolation, lipid type, mild	X			X				X	X
Fibrin thrombus			X
Heart:
-Infiltration, leukocyte, predominantly mononuclear, minimal		X				X			X
Myofiber separation and vaculation, minimal (suspect artifact)		X	X						X
Kidney:
- Infiltration, leukocyte, predominantly mononuclear, minimal	X	X		X		X		X
Tubule vacuolation, minimal					X				X
Fibrin or other extracellular matrix, glomerulus								X