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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Am J Geriatr Psychiatry. 2014 May 17;23(2):200–214. doi: 10.1016/j.jagp.2014.05.003

Table 3.

Summary of functional connectivity data

Condition Seed Controls vs. GAD (x/y/z; kE) Pre- vs. post-treatment GAD (x/y/z; kE)
Controls > GAD GAD > Controls Pre > Post Post > Pre
Worry Induction Left anterior
insula		 Right OFC: (10/56/−12; kE
=388; t=3.83; df=54)		 Left precentral gyrus [BA6]:
(−54/2/42; kE=163; t=6.3,
df=11)
Left medial frontal gyrus
[BA6]: (−2/34/42; kE=95;
t=6.0; df=11)
Left subgenual cingulate
[BA25]: (−7/22/−14; kE=149;
t=5.43; df=11)		 Right postcentral gyrus
[BA5]: (18/−46/72; kE=76;
t=5.1; df=11)
Left BA46 (dlPFC) Left insula: (−34/−8/12;
kE=730; t=3.99; df=54)
Right insular cortex [BA13]:
(40/−7/13; kE=288; t=4.00;
df=54)		 Left superior frontal gyrus
[BA10]: (−22/63/−2; kE=174;
t=3.71; df=54)
Cerebellar vermis: (6/−52/−2;
kE 261; t=4.14; df=54)
Left fusiform gyrus: (−35/−
66/−14; kE=263; t=3.44;
df=54)		 Left inferior frontal gyrus
[BA45]: (−54/20/12; kE=55;
t=7.3; df=11)
Right OFC [BA47]: (46/34/−
12; kE=275; t=6.7; df=u)
BNST Left thalamus: (−18/−22/10;
kE=190;
t=4.35; df=54)		 Anterior cingulate
(subgenual) [BA24]: (4/28/−
6; kE=172; t=3.95; df=54)		 Left insula [BA13]: (−38/−
20/10; kE=146; t=7.8; df=11)
Right supramarginal gyrus
[BA2]: (48/−33/42; kE =456;
t=7.1; df=11)		 Left frontal medial gyrus: (−
11/37/38; kE=527;
t=6.6;df=11)
Left frontal superior gyrus: (−
18/50/30; kE=527;t= 5.6;
df=11)
Left lingual gyrus: (−15/−76/−
7; kE=60; t=5.68; df=11)
Left inferior frontal gyrus
[BA46]:
(-44/40/16; kE=52,
t=5.2; df=11; p=0.00014,
threshold p>0.00012)
PVN Middle frontal gyrus [BA6]:
(−24/−12/52; kE=577; t=4.25;
df=54)		 Left OFC [BA11]: (−26/28/−
18; kE=35; t=6.4; df=11)
Right supramarginal gyrus
[BA40]: (51/−32/42; kE=601;
t=6.6; df=11)
Left insula [BA13]: (−42/−
20/10, kE=74; t=5.79; df=11)
Right middle frontal gyrus
[BA8]: (32/13/42; kE=246;
t=5.4; df=11)		 Left medial frontal gyrus
[BA9]: (−15/33/30; kE =224;
t=5.3; df=11)
Left lingual gyrus [BA18]: (−
9/−76/−5, kE =187; t=5.3;
df=11)
Worry Reappraisal Left anterior
insula		 Left medial frontal gyrus
[BA6]: (−8/−16/54, kE=469;
t=4.61; df=54)
dACC [BA24]: (−6/−12/43;
kE=469; t=3.85; df=54)
Right superior frontal gyrus:
(18/44/34; t=4.44; kE=80)
Middle frontal gyrus: (28/−
14/48; kE=289; t=4.26;
df=54)		 Left temporal pole [BA38]: (−
48/16/−12; kE=187; t=4.49;
df=54)
Left hippocampus: (−30/−
38/0; kE=285; t=4.28; df=54)
Right superior frontal gyrus
[BA6]: (18/20/60; kE=126;
t=4.20; df=54)		 Left anterior cingulate
[BA32]: (−7/35/28; kE=202;
t=12.7; df=11)
Left middle temporal gyrus:
(−44/4/−37; kE=294; t=9.1;
df=11)
Right temporal pole [BA38]:
(42/16/−38; kE=75; t=7.4;
df=11)		 Cerebellar vermis: (−1/−44/−
6; kE=138; t=8.5; df=11)
Left BA46 (dlPFC) Right medial frontal gyrus
[BA9]: (12/40/26; kE=173;
t=4.41; df=54)
Right superior frontal gyrus
[BA10]: (9/59/−7; kE=146;
t=3.46; df=54)		 Left fusiform gyrus: (−18/−
34/−16; kE=91; t=4.59; df=54)		 Left fusiform gyrus: (−40/−
42/−16; kE=301; t=11.6;
df=11)
Left rectus [BA11]: (−1/21/−
24; kE=155; t=9.1; df=11)
Left limbic lobe (Uncus): (−
32/−2/−34; kE=107; t=8.4;
df=11)		 Right supramarginal gyrus
[BA40]: (46/−36/60; kE=166;
t=13.2; df=11)
Right superior frontal gyrus
[BA11]: (18/51/−18; kE=52; t=
7.2; df=11)
Right inferior frontal gyrus
[BA47]: (54/19/0.6; kE=101;
t= 6.9; df=11)
Middle cingulate gyrus: (7/−
32/41; kE=102; t=6.6; df=11)
Right cuneus: (12/−98/16;
kE=66; t=7.7; df=11)
BNST Left medial frontal gyrus: (−
18/56/0; kE=52; t=4.08;
df=54)		 Left frontal middle gyrus
[BA6]: (−25/7/63; kE=203;
t=7.4; df=11)		 Right lingual gyrus [BA19]:
(24/−68/−2.70; kE=355;
t=8.9; df=11)
Right frontal superior gyrus
[BA10]: (34/62/16; kE= 179,
t=5.4; df=ii; p=0.0003,
threshold p>0.00017)
PVN Right amygdala: (22/−4/−18;
kE=217; t=4.88; df=54)		 Right transverse temporal
gyrus [BA41]: (55/−24/12,
kE=97; t= 6.5; df=11)
Left putamen: (−24/−4/4,
kE=56; t=7.1; df=11)
Middle cingulate gyrus
[BA31]: (−6/−30/40, kE=125,
p=0.0002, thresholdp>0.00017; t= 4.5; df=11 		Right superior frontal gyrus:
(21/55/14, kE=115, p=0.0002,
thresholdp>0.00017; t=5.7;
df=11)

BA = Brodmann Area; BNST = bed nucleus of the stria terminalis; dACC = dorsal anterior cingulate cortex; GAD = generalized anxiety disorder; OFC = orbitofrontal cortex; PVN = periventricular nucleus of the hypothalamus. In italics, results that did not survive multiple comparison correction. All other results are significant are a corrected p ≤ 0.05. t=T-test (peak-level); df= degrees of freedom