. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Am J Geriatr Psychiatry. 2014 May 17;23(2):200–214. doi: 10.1016/j.jagp.2014.05.003

Table 4.

Proposed deficits in emotion regulation in late-life GAD

Domain	Deficit	Functional connectivity findings
Emotion Generation (Worry Induction)	Excessive attribution of negative affective value to worry statements	Greater Insula-OFC connectivity during worry induction in pre-treatment GAD (compared with non-anxious participants and with post-treatment GAD)
Emotion Generation (Worry Induction)	Excessive attribution of threat	Greater BNST-Insula connectivity during worry induction in GAD
Emotion Regulation (Worry reappraisal)	Failure to reappraise worry	Lower insula-prefrontal connectivity during worry reappraisal in GAD
		Lower prefrontal connectivity (BA46- BA10/BA9) in GAD during worry reappraisal
		Greater prefrontal connectivity in post treatment GAD during worry reappraisal
	Rigid executive network control	Similar nodes connected during both induction and reappraisal of worry in GAD
	Increased stress response during reappraisal	Greater BNST-subgenual cingulate connectivity in pre-treatment GAD during worry induction
	Increased stress response during reappraisal	Greater PVN-Amygdala connectivity in pre- treatment GAD during worry reappraisal