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. 2014 Nov 13;13:151. doi: 10.1186/s12933-014-0151-6

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© Zhu et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunization with AGE-LDL using Alum as adjuvant reduced atherosclerotic lesion burden of diabetic apoE −/− and LDLR-/ mice. A and B, Representative photomicrographs showing oil red O stained en face preparations of aortas (n = 10 in each group). C. Percentage of plaque area of total aortic area of diabetic apoE−/− and LDLR−/− mice treated with Alum adjuvant (bar with stripes), Alum + AGE-LDL immunization (black bar), and PBS treated controls (white bar). Mean ± SD values are shown. *indicates p < 0.05 vs. control, **indicates p < 0.01 vs. control, #indicates p < 0.05 vs. Alum adjuvant.