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. 2014 Oct 24;18(5):580. doi: 10.1186/s13054-014-0580-3

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© Ranzani et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Interrupted time series from the autoregressive integrated moving average model. Length of mechanical ventilation (MV) (A) and adjusted midazolam consumption (B) over time. Solid black circles represent the average data per month. Solid black line represents the fitted line for the observed data after the protocol implementation. Gray dashed line represents the forecasted values from the model if the protocol was not implemented during the period. Yellow dashed line represents when the intervention began.