Table 1.

Overview of the kinetic parameters in the model

Parameter	Description	Value (s -1)
k on	Influx of transferases at initiation site	2.4 (one enzyme models)
		0.01 (two enzyme models)
k off	Release rate of transferase from nucleosome	0.1
k transferase	Modification rate of nucleosome	1000
k neighbor	Modification rate of neighboring nucleosome	0.2
k slide	1D diffusion rate over the chromatin	0.6
k recruitment	Influx of transferases at modified nucleosome	0.24-4.8
k demodification	Rate constant of demodification	2.4
k interaction	Interaction frequency	0.01-1

The derivation and calculations of the kinetic parameters can be found in the Methods section.