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. 2014 Sep 10;16(8):665–677. doi: 10.1016/j.neo.2014.07.009

Figure 5.

Figure 5

Effect of YF479 on blocking breast tumor metastases to the lung in an experimental animal model. After tail vein injection of MDA-MB231-luc cells (1 × 106), the mice were divided into four groups based on the initial bioluminescence images (n = 7 per group). Bioluminescence images were obtained using a Xenogen IVIS 2000 Biophotonic Imager at indicated times. (A) Representative bioluminescence images of mice inoculated with human MDA-MB231-luc cells in control and treatment groups. (B) Quantification of A. (C) YF479 upregulated cleaved-caspase 3 expression and suppressed the expression of PCNA. *P < 0.05; *** P < .001 versus control.