Figure 6.
YF479 suppresses local-regional recurrence and distant metastasis, and increases survival of mice with breast cancer. 4 T1-luc cells (1 × 105) were injected into BALB/c mouse mammary fat pads. Primary mammary tumors were surgically removed 8 days after inoculation, and mice were treated with DMSO, YF479 (30 mg/kg) or SAHA (30 mg/kg) (n = 11 per group). (A) Representative bioluminescent images of mice in different groups. (B) Incidence of LRR and distant metastasis in each group. (C) Overall survival rate according to treatment in the adjuvant treatment model was shown. Time scale relates to days after tumor resection.