Table 1.

Allelic frequencies of hs1.2 enhancer in children (A) and adults (B) divided for the serum levels of Ig

A		IgM			IgG			IgA
		Low	Medium	High	Low	Medium	High	Low	Medium	High
Children (f)	ALLELE 1	0.47 ± 0.03	0.44 ± 0.04	0.02 ± 0.01	0.48 ± 0.05	0.41 ± 0.04	0.05 ± 0.02	0.49 ± 0.04	0.40 ± 0.06	0.05 ± 0.03
	ALLELE 2	0.43 ± 0.04	0.46 ± 0.04	0.81 ± 0.04	0.44 ± 0.03	0.47 ± 0.06	0.79 ± 0.04	0.39 ± 0.05	0.49 ± 0.04	0.82 ± 0.03
	ALLELE 3	0	0	0	0	0	0	0	0	0
	ALLELE 4	0.1 ± 0.03	0.1 ± 0.02	0.17 ± 0.03	0.08 ± 0.02	0.12 ± 0.03	0.16 ± 0.03	0.12 ± 0.03	0.11 ± 0.03	0.13 ± 0.02
	n.	60	70	60	60	70	60	60	70	60
B
Adults (f)	ALLELE 1	0.29 ± 0.03	0.32 ± 0.03	0.25 ± 0.02	0.30 ± 0.02	0.30 ± 0.02	0.26 ± 0.02	0.34 ± 0.03	0.26 ± 0.04	0.27 ± 002
	ALLELE 2	0.56 ± 0.04	0.54 ± 0.02	0.58 ± 0.03	0.54 ± 0.04	0.55 ± 0.06	0.58 ± 0.04	0.52 ± 0.04	0.58 ± 0.03	0.57 ± 0.07
	ALLELE 3	0	0.01 ± 0.01	001 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0	0.01 ± 0.01
	ALLELE 4	0.15 ± 0.01	0.13 ± 0.02	0.16 ± 0.01	0.15 ± 0,01	0.14 ± 0.01	0.16 ± 0.02	0.13 ± 0.03	0.16 ± 0.01	0.15 ± 0.02
	n.	110	120	110	110	120	110	110	120	110

(A) pValue IgM LOW vs HIGH = 3.9E-12; LOW vs MEDIUM = 8E-04; MEDIUM vs HIGH = 5.2E-10; pValue IgA LOW vs HIGH = 5.6E-11; LOW vs MEDIUM = 1E-03; MEDIUM vs HIGH = 9.9E-08; pValue IgG LOW vs HIGH = 8.3E-11; LOW vs MEDIUM = 1E-03; MEDIUM vs HIGH = 4.6E-08.

(B) pValue IgM LOW vs HIGH = 0.92; LOW vs MEDIUM = 0.97; MEDIUM vs HIGH = 0.79; pValue IgG LOW vs HIGH = 0.53; LOW vs MEDIUM = 0.61; MEDIUM vs HIGH = 0.99; pValue IgA LOW vs HIGH 0.14; LOW vs MEDIUM 0.11; MEDIUM vs HIGH 0.79.

(n. = Number of subjects).