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Schematic representation of HGV-Apoptin mechanism of action in cancer cells. HGV-Apoptin activation and nuclear accumulation induces the nuclear export of nur77, which might induce the activation of the BCL-2 family members of proteins, leading to MOMP and the subsequent cytoplasmic release of AIF and cyt c leading to apoptosis through APAF1 activation, the apoptosome formation, and the subsequent caspase activation.
