Table 2.
Summary of previous studies on TRPV1 and synaptic plasticity in the brain
| Brain area | Species | Method | Plasticity type | Key findings | Reference |
|---|---|---|---|---|---|
| Hippocampus |
Mouse |
fEPSP |
LTP |
Reduced LTP in the CA1 region in TRPV1-deficient mice |
[21] |
| CA1 region |
|
|
|
||
| Hippocampus |
Rat |
fEPSP |
LTP and LTD |
TRPV1 agonists facilitated LTP but suppressed LTD induction and thus antagonized the stress effect on synaptic plasticity in the CA1 region |
[22] |
| CA1 region |
|
|
|
||
| Hippocampus |
Rat |
fEPSP |
LTP and LTD |
TRPV1 activation facilitates LTP induction via disinhibition, reduces DHPG-induced acute depression, but does not affect LFS-induced LTD in CA1 |
[31] |
| CA1 region |
|
|
|
||
| Hippocampus |
Rat |
EPSC |
LTD |
TRPV1 channels activated by 12-(S)-HPETE mediate a presynaptic form of LTD in the excitatory synapses on CA1 interneurons |
[24] |
| CA1 region |
|
|
|
||
| Hippocampus |
Rat |
EPSC |
LTD |
Calcineurin is required for TRPV1-induced LTD in the CA1 interneurons |
[32] |
| CA1 region |
|
|
|
||
| Hippocampus |
Mouse |
fEPSP and EPSC |
LTP and LTD |
Loss of interneuron LTD and attenuated pyramidal cell LTP in the TRPV1 knockout mice |
[23] |
| CA1 region |
|
|
|
||
| Dentate gyrus |
Rat and mouse |
EPSC |
LTD |
TRNPV1 channels activated by anandamide mediate a postsynaptic form of LTD in dentate granular cells |
[25] |
| Superior colliculus |
Mouse |
fEPSP |
LTD |
TRPV1 channels mediate LTD in the developing superior colliculus |
[33] |
| Nucleus accumbens |
Mouse |
EPSC |
LTD |
TRPV1 channels activated by endocannabinoid mediate a postsynaptic form of LTD in medium spiny neurons of the indirect pathway |
[26] |
| BNST and dorsal striatum |
Rat |
fEPSP and EPSC |
LTD |
TRPV1 channels activated by anandamide mediate LTD in the BNST but not dorsal striatum |
[34] |
| Lateral amygdala |
Mouse |
fEPSP |
LTP |
TRPV1 agonist affected the LTP in a way that is dependent on the anesthetic |
[35] |
| ACC | Mouse | fEPSP | LTP and LTD | TRPV1 antagonosts had no effect on cingulate LTP or LTD induction | The present study |
Notes: 12-(S)-HPETE, 12(S)-hydroperoxyeicosa-5Z, 8Z, 10E, 14Z-tetraenoic acid; ACC, anterior cingulate cortex; BNST, bed nucleus of the stria terminalis; DHPG, (RS)-3,5-dihydroxy phenylglycine; EPSC, excitatory postsynaptic current; fEPSP, field excitatory postsynaptic potential; LFS, low-frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; TRPV1, transient receptor potential vanilloid type 1.