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. 2013 Dec 5;7:132. doi: 10.1186/1752-0509-7-132

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Copyright © 2013 Ghosh et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Distribution of essential proteins based upon percentage of conserved residues seen in the protein sequence (blue bar) and those forming binding pockets (red bar). X-axis represents the percentage of residues conserved (residues with conservation score ≥ 50, see Equation 8) in the protein (gene) or binding pockets and y-axis represents the frequency of these proteins in the final set studied (269 for structure analysis (red), 283 for sequence analysis (blue)). Essential genes are shown to be composed of high percentage of conserved residue and the corresponding pockets (red) are also shown to have more number of conserved residues.