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Immunostainings of phosphorylated histone H2A.X in MCF7 cells. (A) On MCMBP knockdown, the DNA stress response checkpoint is activated, as illustrated by the enhanced phosphorylation of the histone H2A.X. (B) qPCR analysis of the different MCF7 lines used in the experiment; 80% of the MCMBP transcript is reduced in the stable knocked down MCF7 line. (C) Quantitation of the histone H2A.X foci observed in the control nuclei in comparison with the MCMBP knocked down cells.
