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Dose-volume effects in serum proteome changes. Panel A – Averaged Dose-Volume Histogram; marked are doses corresponding to deciles of the area under curve of the histogram. Panel B - Numbers of serum proteome features correlating with tissue volume irradiated at a given dose for the AΔB, BΔC, CΔD and AΔD changes; p = 0.05 was selected as a statistical significance threshold.
