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. Author manuscript; available in PMC: 2014 Nov 18.
Published in final edited form as: Neuroscience. 2010 Nov 18;174:71–83. doi: 10.1016/j.neuroscience.2010.11.025

Figure 6. Statistical path analyses for the evaluation of the influence of intrinsic and extrinsic sources of early APP(swe)-related pathology [W0-2, β-amyloid(4-10)] on retrosplenial cortex dysfunction (c-Fos) at 5 months.

Figure 6

Anterior thalamus W0-2 seems related to that found in the retrosplenial cortex, which in turn affects c-Fos induction. In contrast, rostral hippocampal W0-2 itself is only a good predictor of retrosplenial cortex c-Fos activity. The blunt arrow represents inhibition while normal arrows represent increase/activation. Italicized values represent the coefficient of determination, a value representing the amount of variance accounted for by the explanatory variables. ADTN, anterior thalamic nuclei; HPC, hippocampus; Rgb, retrosplenial granular b. *, p < 0.05; **, p < 0.005; ***, p < 0.001; ns, non-significant (p > 0.12).