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. 2014 Nov 18;5:246. doi: 10.3389/fphar.2014.00246

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Copyright © 2014 Phillips, Yoon, Young and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Utility of peripheral markers to predict inhibition in the target tissue (brain) for 5000 simulations. (A) Spot percent AChE inhibition in the brain vs. spot percent AChE inhibition in red blood cells, taken at the same time as the urine sampling; (B) 24-h averaged AChE inhibition in brain vs. 24-h averaged AChE inhibition in RBC (time averaging was over the 24 h prior to urine sampling); (C) Spot percent AChE inhibition in the brain vs. spot 1-N concentrations in urine (nM); (D) Spot percent AChE inhibition in the brain vs. spot carbaryl concentrations in plasma (pM).