Figure 4. Recurrent miRNA-target network are enriched for oncomir and oncogenes.

(a) Venn diagrams displaying the overlaps between the miRNA (left panel) or targets (right panel) involved (top) or not involved (bottom) in the recurrent network and the known cancer miRNAs²¹,²² or cancer genes²³, respectively. P-values indicated above were computed by hypergeometric test. (b) Select recurrent oncomir-oncogene subnetwork involving miR-200 family (miR-200a/b/c/141/429) (red diamonds) and their target genes (blue ellipses). The node size and the edge width are proportional to the in/out-degree and recurrence posterior in the overall oncogene-oncomir network, respectively.