Figure 7. An example of the prognostic and recurrent miRNA-target interaction.

(a). Scatterplots of miR-200c-3p and LYVE1 expression across samples in CRC and LUSC illustrate a recurrent negative expression correlation pattern (PanMiRa Bayesian joint posterior > 0.51 across all cancers) and cancer-specific Pearson correlation equal to −0.38 and −0.30, respectively. (b). Kaplan-Meier survival plots. Samples with the corresponding miR-200c-3p or LYVE1 expression higher (red dash) and lower (blue dot) than the sample means were divided into two groups, which were subject to KM survival estimates³⁹. The fit was plotted as KM survival plot for CRC (upper panels) and LUSC (lower panels). P-values indicated above were computed by log-rank test.