Table 2. Functional enrichment of genes involved in the recurrent interactions.
| Database | Term | Hits | Total Hits | p-value | q-value |
|---|---|---|---|---|---|
| UniProt | Extracellular matrix (ECM) | 62 | 241 | 6.7E-26 | 3.7E-23 |
| GO-BP | GO:0030198 extracellular matrix organization | 33 | 104 | 7.9E-16 | 2.2E-12 |
| GO-BP | GO:0007155 cell adhesion | 91 | 700 | 8.3E-14 | 1.2E-10 |
| GO-BP | GO:0022610 biological adhesion | 91 | 701 | 8.9E-14 | 8.5E-11 |
| GO-BP | GO:0043062 extracellular structure organization | 35 | 163 | 2.2E-11 | 1.3E-08 |
| KEGG | hsa04510:Focal adhesion | 38 | 201 | 7.6E-11 | 1.2E-08 |
| GO-MF | GO:0019838 growth factor binding | 25 | 105 | 4.2E-09 | 1.7E-06 |
| KEGG | hsa04512:ECM-receptor interaction | 22 | 84 | 4.3E-09 | 3.3E-07 |
| GO-BP | GO:0051271 negative regulation of cell motion | 15 | 63 | 8.3E-06 | 1.7E-03 |
| GO-CC | GO:0044459 plasma membrane part | 171 | 2203 | 1.1E-05 | 2.9E-04 |
| GO-BP | GO:0030155 regulation of cell adhesion | 22 | 137 | 2.6E-05 | 3.8E-03 |
| GO-BP | GO:0048771 tissue remodeling | 13 | 56 | 5.3E-05 | 6.3E-03 |
| GO-BP | GO:0030334 regulation of cell migration | 24 | 169 | 7.6E-05 | 8.7E-03 |
| GO-BP | GO:0001936 regulation of endothelial cell prolif. | 9 | 32 | 3.1E-04 | 3.0E-02 |
| GO-BP | GO:0002039 p53 binding | 6 | 17 | 2.1E-03 | 1.1E-01 |
| GO-MF | GO:0046332 SMAD binding | 9 | 46 | 4.3E-03 | 1.8E-01 |
| KEGG | hsa05200:Pathways in cancer | 31 | 328 | 5.7E-03 | 1.0E-01 |
| KEGG | hsa04350:TGF-beta signaling pathway | 12 | 87 | 9.7E-03 | 1.3E-01 |
Targets from recurrent miRNA-target interactions were subjected to functional enrichment tests using DAVID29. The top functional terms were listed above along with its database sources, (total) number of target genes, p-value, and q-value (Benjamini-Hochberg adjusted).