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Transverse electron microscopy with OTAP labeling solid lipid-filled particles. (A) A 2-month-old WT mouse fed a normal diet shows no solid particles. (B) A 2-month-old apoB100 mouse. Arrows point to two small solid particles that measure 95 μm and the larger particle is 125 μm in diameter (black arrows). (C) A different 2-month-old apoB100 mouse on a normal diet shows multiple solid particles (some indicated by white arrows) that measure from 60 to 200 μm. Scale bar: 500 nm.
