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. 2014 Nov 17;55(11):7285–7295. doi: 10.1167/iovs.14-15195

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Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

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Transverse electron microscopy of 12-month-old apoB100 mice show aging, but not AMD changes. (A) A 12-month-old WT mouse with normal RPE including basal infoldings (BI), BrM, and CC endothelium. (B) A 12-month-old apoB100 mouse with preserved RPE including mitochondria and BI. Thin, homogeneous BlamDs appear between the RPE and its basement membrane (arrows). (C) A 12-month-old apoB100 mouse with outer collagenous layer (OCL) deposit, a normal aging change. (D) A 12-month-old apoB100 mouse with small cytoplasmic vacuole (V). Bruch's membrane has a redundant choriocapillaris basement membrane (arrows). Scale bar: 300 nm.