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. 2014 Nov 17;55(11):7285–7295. doi: 10.1167/iovs.14-15195

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Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

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Transverse electron microscopy of 18-month-old ApoB100 mice shows aging, but no AMD changes. (A) An 18-month-old WT mouse with normal appearing RPE including mitochondria (*) and BI, and BrM. Note undigested photoreceptor outer segment (arrow). (B) An 18-month-old apoB100 mouse with preserved RPE BI. Bruch's membrane has a vacuole that is suggestive of lipid accumulation (arrow). (C) An 18-month-old apoB100 mouse with mild RPE abnormality including partially digested photoreceptor outer segment (arrow) in the basal RPE. Note the preserved basal infoldings. (D) An 18-month-old apoB100 mouse with preserved RPE and thin, homogeneous basal laminar deposits (BlamD, arrows). Scale bar: 300 nm.