Table 1.

Major inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Age 18 or older Type 1 or Type 2 diabetes Able and willing to provide consent and agrees to comply with study procedures and follow‐up evaluations Foot ulcer size >1 cm2 and <25 cm2 Ulcer duration of ≥4 weeks, unresponsive to standard wound care No clinical signs of infection Serum creatinine <3·0 mg/dl HgA1c <12% Adequate circulation to the affected extremity as demonstrated by dorsum transcutaneous oxygen test (TcPO2) ≥ 30 mmHg, or ABI between 0·7 and 1·2, or triphasic or biphasic doppler arterial waveforms at the ankle of affected leg	Participating in another clinical trial Charcot foot Index ulcer probing to bone Currently receiving radiation or chemotherapy Known or suspected malignancy of current ulcer Diagnosis of autoimmune connective tissue disease Received a biomedical or topical growth factor for their wound within the previous 30 days Pregnant or breast feeding Taking medications considered to be immune system modulators Allergy to gentamicin or streptomycin.