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. 2014 Jan 7;34(3):277–283. doi: 10.1111/neup.12094

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© 2014 The Authors. Neuropathology published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Society of Neuropathology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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The cerebellar cortex of a non-surviving rabbit from the non-treatment group showing necrosis of Purkinje cells (arrowheads). Immunohistochemistry of the cerebellum reveals abundant rabies virus (RABV) antigen in Purkinje and granular cells (inset, A). The cerebellar cortex of a surviving rabbit from the subcutaneous (SC)/intrathecal (IT) group showed the loss of Purkinje and granular cells together with gliosis of the molecular layer. RABV antigen is not found in the cerebellum (inset, B). Scale bar represents 50 μm .