Table 2.

Diuretic dosing for acute HF according to the ASCEND-HF model

Creatinine clearance*	Patient	Initial IV dose§	Maintenance dose
>60 mL/min/1.73 m2	New-onset HF or no maintenance diuretic therapy Established HF or chronic oral diuretic therapy	Furosemide 20–40 mg 2–3 times daily Furosemide bolus equivalent to oral dose	Lowest diuretic dose that allows for clinical stability is the ideal dose
<60 mL/min/1.73 m2	New-onset HF or no maintenance diuretic therapy Established HF or chronic oral diuretic therapy	Furosemide 20–80 mg 2–3 times daily Furosemide bolus equivalent to oral dose

Notes:

^*Creatinine clearance is calculated from the Cockroft–Gault or Modified Diet in Renal Disease formula.

^§Intravenous continuous furosemide at doses of 5–20 mg/hour is also an option. Data from Ezekowitz et al.33

Abbreviations: HF, heart failure; IV, intravenous.