Table 3.
Efficacy, safety, and predictability comparison of WF-optimized and WF-guided hyperopic laser in situ keratomileusis
| Parameter | Postoperative month 1
|
Postoperative month 3
|
Postoperative month 6
|
Postoperative month 12
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percent, 95% CI
|
Percent, 95% CI
|
Percent, 95% CI
|
Percent, 95% CI
|
|||||||||
| WFG | WFO | Pa | WFG | WFO | Pa | WFG | WFO | Pa | WFG | WFO | Pa | |
| Efficacy (UDVA) | ||||||||||||
| 20/16 or better | 54.5, 23.4–83.3 | 63.6, 30.8–89.1 | 1.00 | 63.6, 30.8–89.1 | 72.7, 39.0–94.0 | 1.00 | 81.8, 48.2–97.7 | 54.5, 23.4–83.3 | 0.37 | 72.7, 39.0–94.0 | 72.7, 39.0–94.0 | 1.00 |
| 20/20 or better | 72.7, 39.0–94.0 | 90.9, 58.7–99.8 | 0.63 | 72.7, 39.0–94.0 | 81.8, 48.2–97.7 | 1.00 | 90.9, 58.7–99.8 | 90.9, 58.7–99.8 | 1.00 | 100.0, 71.5–100.0 | 90.9, 58.7–99.8 | 1.00 |
| 20/30 or better | 90.9, 58.7–99.8 | 90.9, 58.7–99.8 | 1.00 | 81.8, 48.2–97.7 | 81.8, 48.2–97.7 | 1.00 | 100.0, 71.5–100.0 | 90.9, 58.7–99.8 | 1.00 | 100.0, 71.5–100.0 | 90.9, 58.7–99.8 | 1.00 |
| 20/40 or better | 100.0, 71.5–100.0 | 90.9, 58.7–99.8 | 1.00 | 81.8, 48.2–97.7 | 90.9, 58.7–99.8 | 1.00 | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 |
| 20/50 or better | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 | 90.9, 58.7–99.8 | 90.9, 58.7–99.8 | 1.00 | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 |
| Safety (CDVA) | ||||||||||||
| Loss of 2 lines or more | 9.1, 0.2–41.3 | 9.1, 0.2–41.3 | 1.00 | 9.1, 0.2–41.3 | 0.0, 0.0–28.5 | 1.00 | 18.2, 2.3–51.8 | 0.0, 0.0–28.5 | 0.50 | 0.0, 0.0–28.5 | 0.0, 0.0–28.5 | 1.00 |
| Loss of 1 line | 9.1, 0.2–41.3 | 27.3, 6.0–61.0 | 0.50 | 9.1, 0.2–41.3 | 27.3, 6.0–61.0 | 0.63 | 9.1, 0.2–41.3 | 18.2, 2.3–51.8 | 1.00 | 18.2, 2.3–51.8 | 18.2, 2.3–51.8 | 1.00 |
| No loss or gain of lines | 54.5, 234–83.3 | 45.5, 16.7–76.6 | 1.00 | 36.4, 10.9–69.2 | 36.4, 10.9–69.2 | 1.00 | 27.3, 6.0–61.0 | 36.4, 10.9–69.2 | 1.00 | 45.5, 16.7–76.6 | 72.7, 39.0–940 | 0.37 |
| Gain of 1 line | 18.2, 2.3–51.8 | 9.1, 0.2–41.3 | 1.00 | 18.2, 2.3–51.8 | 27.3, 6.0–61.0 | 1.00 | 27.3, 6.0–61.0 | 45.5, 16.7–76.6 | 0.63 | 27.3, 6.0–61.0 | 9.1, 0.2–41.3 | 0.63 |
| Gain of 2 lines or more | 9.1, 0.2–41.3 | 9.1, 0.2–41.3 | 1.00 | 18.2, 2.3–51.8 | 0.0, 0.0–28.5 | 1.00 | 18.2, 2.3–51.8 | 0.0, 0.0–28.5 | 1.00 | 9.1, 0.2–41.3 | 0.0, 0.0–28.5 | 1.00 |
| Predictability | ||||||||||||
| ±0.25 D of emmetropia | 45.5, 16.7–76.6 | 72.7, 39.0–94.0 | 0.25 | 72.7, 39.0–94.0 | 63.6, 30.8–89.1 | 1.00 | 63.6, 30.8–89.1 | 54.5, 234–83.3 | 1.00 | 81.8, 48.2–97.7 | 36.4, 10.9–69.2 | 0.13 |
| ±0.50 D of emmetropia | 90.9, 58.7–99.8 | 90.9, 58.7–99.8 | 1.00 | 81.8, 48.2–97.7 | 72.7, 39.0–940 | 1.00 | 81.8, 48.2–97.7 | 90.9, 58.7–99.8 | 1.00 | 90.9, 58.7–99.8 | 72.7, 39.0–940 | 0.50 |
| ±1.00 D of emmetropia | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 | 90.9, 58.7–99.8 | 90.9, 58.7–99.8 | 1.00 | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 | 100.0, 71.5–100.0 | 100.0, 71.5–100.0 | 1.00 |
Notes:
a
P-values for proportions are by McNemar’s exact test for paired observations from a small sample.
Abbreviations: CDVA, corrected distance visual acuity; CI, confidence interval; D, diopter; UDVA, uncorrected distance visual acuity; WF, wavefront; WFO, WF-optimized; WFG, WF-guided.