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. Author manuscript; available in PMC: 2014 Nov 18.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2008 Jul;17(4):408–415. doi: 10.1097/MNH.0b013e3283040c99

Figure 1. Vitamin D Metabolism and Actions.

Figure 1

The calciotropic functions of 1,25-(OH)2-D include the physiological regulation of calcium transport and bone mineralization. The synthesis of circulating 1,25-(OH)2-D which mediates these calciotropic actions is tightly regulated. Non-calciotropic actions involve the activation of vitamin D receptors (VDRs) by locally produced 1,25-(OH)2-D in a number of tissues in a paracrine and autocrine fashion.