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. 2014 Nov 17;211(12):2397–2410. doi: 10.1084/jem.20140625

Figure 4.

Figure 4.

IL-17A deficiency reduces influenza-induced immune injury in small intestine but not in lung. (A) The pathology of lung and small intestine from control and PK136-treated mice was assayed 6 d after PR8 infection. (B) The pathology of lung and small intestine from WT and Tcrd−/− mice was assayed 6 d after PR8 infection. (C) The pathology of lung and small intestine from WT and IL-17A−/− mice was assayed 6 d after PR8 infection. (D) IL-17A and IL-17F expressions in the lung from WT mice were detected by real-time PCR 6 d after PR8 infection. (E) Body weight of WT and IL-17A−/− mice was monitored after PR8 infection. (F) Evans blue dye concentration in BALF from WT and IL-17A−/− mice was determined by spectrophotometer 6 d after PR8 infection. (G and H) Total protein (G) and lactate dehydrogenase (H) levels in BALF from WT and IL-17A−/− mice were determined by ELISA 6 d after PR8 infection. All tissue sections were stained with H&E. Bars, 100 µm. Data represent two independent experiments with five mice/group in E–H or three mice/group in A–D. Data are expressed as mean ± SEM by a Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; NS: not significant.